|The cox-1 n/a (Catalog #MBS841706) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase.
Screening/studying/characterizing COX-1 inhibitors. Researchers should empirically determine the suitability of the cox-1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The cox-1 n/a product has the following accession number(s) (GI #185133942) (NCBI Accession #NP_001117833.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given assay kit. We\'ve tested the Cyclooxygenase-1 (COX-1) Inhibitor Screening Kit (Fluorometric) with the following immunoassay(s):
Typical Testing Data/Standard Curve (for reference only)
Product Information: COX-1 Inhibitor Screening Kit (Fluorometric): Simple method to screen/study/characterize Cyclooxygenase-1 Inhibitors, includes COX-1 Inhibitor, SC560. Convenient & Reliable. 100 Assays.
Background: Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 220.127.116.11), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain. MyBioSource\'s COX-1 Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of COX-1 inhibitors. The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.
Summary: Detection method- Fluorescence (Ex/Em 535/587 nm)
Applications- Screening/studying/characterizing COX-1 inhibitors.
Detection Method: Fluorescence (Ex/Em 535/587 nm)
Features & Benefits: Simple method to screen COX-1 inhibitors
Includes Inhibitor Control, SC560.