|The Mammalian CETP II n/a (Catalog #MBS841651) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The MBS841651 Assay Kit recognizes Mammalian CETP II.
Screening/studying/characterizing CETP inhibitors. Researchers should empirically determine the suitability of the CETP II n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
(Or you can also download the PDF Manual
for complete product instructions).
Please refer to the product datasheet for known applications of a given assay kit. We\'ve tested the CETP Inhibitor Screening Kit (Fluorometric) II with the following immunoassay(s):
Typical Testing Data/Standard Curve (for reference only)
Background/Introduction: Cholesteryl ester transfer protein (CETP) is a plasma protein that transfers a cholesteryl ester from HDL to LDL or VLDL in exchange for a triglyceride. HDL plays an important role in lipid metabolism and cardiovascular health. HDL transports cholesterol to the liver for excretion or to steroidogenic tissues for steroid synthesis. HDL also plays an important role in the reverse cholesterol transport pathway, removing cholesterol from lipid-filled macrophages, protecting against atherosclerosis. Because of this function, CETP is viewed as a target to increase HDL, with CETP inhibition being an active area of research and several CETP inhibitors at various stages of drug development. CETP Inhibitor Screening Kit uses a self-quenched fluorescent neutral lipid that can be measured when transferred to an acceptor molecule. The fluorometric intensity is directly proportional to the amount of neutral lipid transfer. Enriched Human CETP from plasma is included for screening. A CETP inhibitor (Anacetrapib) is included as a positive control.